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Complex biologic drugs encounter several challenges in primary packaging. Any interaction between the drug and the prefilled syringe can affect stability and treatment efficacy. For instance, silicone could interact with the drug, and tungsten residues may lead to protein degradation or aggregation.
Alba® syringes represent the best-in-class solution for highly sensitive biologics and ophthalmic applications, minimizing the risk of drug-container interaction and addressing the key requirements of protein-based drugs, and minimizing adsorption, aggregation and inorganic extractable interaction.
All Alba® products have an internal coating based on cross-linked silicone oil. It ensures that particle levels - caused by silicone migration during container storage - are significantly lower than standard siliconization technologies.
Moreover, the internal treatment offers superior and stable gliding performances, reducing the risk of functional issues when combined with autoinjectors, even throughout shelf-life.
Alba® syringes are only available as prefillable solutions in our EZ-fill® configuration.
Watch the video about Alba® syringe features and advantages and discover the manufacturing process.
The low silicone-drug interaction helps to maintain the injection time and dose delivery in combination with an autoinjector.
Alba® breakthrough solution employs a plasma treatment on silicone-oil coating, creating a layer that ensures exceptional stability and performance over time.
| STAKED NEEDLE | LUER | |||
|---|---|---|---|---|
|
sTW |
RNS |
ITC |
OVS |
|
| 0.5mL | ||||
| 1mL long | ||||
| 2.25mL | ||||
Available
Upcoming
Under Development
De-risking drug-silicone interaction
Near-zero subvisible particles level compared to conventional sprayed-on siliconized PFS
Injection Time consistency
Cross-linked coating prevents silicone migration that impacts the extrusion forces and injection time.
Shelf-life improvement
Alba® inner coating does not undergo critical variations after contact with drug products, even in presence of silicone-aggressive or highly concentrated solutions (e.g. surfactants).
Inorganic extractable mitigation
The coating between the drug and the glass reduces the amount of inorganic extractables
Alba® syringes meet the needs of highly sensitive biologic drugs.
Protein-based therapeutics
Ophthalmic applications
mRNA-based applications