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An optimized platform for highly sensitive biologics and the perfect syringe for ophthalmic drugs


An optimized platform for highly sensitive biologics and the perfect syringe for ophthalmic drugs


The sensitivity of drug formulations to one or more elements of their primary packaging has always been a potential problem for the pharmaceutical industry. Biologics in particular are highly sensitive, leading to a higher risk of incompatibility between them and their containers.

This potential incompatibility - and the subsequent instability of formulations - may have multiple causes such as silicone oil droplets, or to interaction between the drug and the surface of the primary container, leading to the protein aggregation phenomenon, or instead to the particles generated by the rubber in the closure system, such as plungers, stoppers, etc. or glass delamination.

Based on these considerations, Ompi decided to initiate a development project with the main purpose of creating a primary packaging platform that could solve the problems associated with the interaction between drugs and their primary packaging.

The result of this development has been the EZ-fill® Alba product range, a sterile glass container platform including vials, cartridges, and syringes, with similar chemical and mechanical characteristics.

All the Alba products have an internal treatment, based on the standard silicone oil, Dow Corning 360, which is cross-linked to the surface of the glass.

Alba treatment replaces the standard siliconization technologies
normally used to create a lubricant layer: this ensures that the number of particles present is normally lower than on the same container where standard siliconization technologies have been used.

It simultaneously ensures high performances in terms of gliding and break-loose forces for syringes and cartridges.

"Alba responds to the key requirements of protein-based drugs and help them to stay compliant with the latest guidelines coming from regulatory bodies"

Alba treatment creates a barrier between the drug and the glass that makes it possible to reduce the amount of inorganic extractables, which is a very good indicator of the container’s propensity to delaminate.

Moreover, thanks to extremely low level of particles the Alba syringe compliant with USP789, the highest standard required for containers used in ophthalmology indications.

Finally, the reduced variability of materials in contact with the drug throughout its life-cycle makes the Alba platform a perfect solution to de-risking the development process, saving on costs and securing a fast introduction to the market.

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EZ-fill® Syringes

Ompi provides a wide range of washed, siliconized and ready-to-fill EZ-fill®syringes.

Syringe components

The components for the syringe system are selected, produced and designed to ease the functionality and compatibility of the full system

Surface Characterization

To deep investigate where the eyes cannot see

Integrated Tip Cap Syringes

The twist-off solution for pre-fillable syringes

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